Rheumatic fever
- usually affects children with recurrent tonsilitis and pharyngitis or young adults (5-15 years).
- tonsilitis-pharyngitis are the most common cause of hematuria in children.
Causes:
- It is triggered by an immune-mediated delayed response to infection with B hemolytic streptococci.
Affects:
- Early in life lead to Arthritis.
- Lately in life lead to Valvitis (specially mitral valve).
🔸Jones criteria for the diagnosis of rheumatic fever:
1) Major manifestations:
• Carditis
• Polyarthritis
• Chorea
• Erythema marginatum
• Subcutaneous nodules
2) Minor manifestations:
• Fever
• Arthralgia
• Previous rheumatic fever
• Raised ESR or CRP
• Leucocytosis
• First-degree AV block
Diagnosis of rheumatic fever depends on:
- two or more major criteria and one minor.
- one major and two or more minor creiteria.
🔸Treatment:
1) first treatment:
- Benzylpenicillin(1200,000 unit single dose /M.I).
2)Second treatment: "pain killers"
- NSAIDs "ibuprofen"
- Prednisolone.
*Aspirin is contraindicated for children, because may lead to Reye syndrome.
3)Third treatment: "Protection"
- Benzathine pencillin (1200,000 I.M every month)
الدكتور / عدنان الادهل
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التصنيفات :
pharmacology